The "Synthetic Biology Weekly" published by the chemical team of Huaan Securities is an industry weekly report for the primary market and the secondary market, summarizing the information of domestic and foreign enterprises in the field of synthetic biology.

At present, the basic frontier research of life science continues to be active, and the wave of biotechnology revolution has swept the world and accelerated its integration into economic and social development, providing new solutions for human beings to deal with major challenges such as life and health, climate change, resource and energy security, and food security. The National Development and Reform Commission issued the "14th Five-Year Plan for the Development of Bioeconomy", and the bio-economy trillion track is about to emerge.

the synthetic biology index is compiled by Hua 'an securities research institute according to the announcement of listed companies, which is composed of 54 listed companies whose businesses involve the application of synthetic biology and related technologies, and is 1000 points based on October 6, 2020. the index covers companies in chemical industry, medicine, industry, food, biomedicine and other fields. This week (2024/01/22-2024/01/26) Huaan Synthetic Biology Index fell 5.45 percentage points to 862.6363. The Shanghai Composite Index rose 2.75 per cent, the GEM index fell 1.92 per cent, and the Huaan Synthetic Biology Index lost 8.20 percentage points to the Shanghai Composite Index and 3.53 percentage points to the GEM index.

kasai biology has obtained the patent of "system for separating and purifying bio-based piperidine". kasai biology (688065) has newly obtained a utility model patent authorization, the patent is called "system for separating and purifying bio-based piperidine", the patent application number is CN 202321722971.8, and the authorization date is January 26, 2024. Patent Abstract: The utility model discloses a system for separating and purifying bio-based piperidine. The system includes a separation device, an ammonia absorption device, a rectification device and a condensation device. The system is aimed at using bio-based pentanediamine as a raw material to prepare bio-based piperidine. The conversion system separates the mixed gas liquid system containing bio-based pentanediamine, bio-based piperidine, water and ammonia after conversion, the purity of the obtained bio-based piperidine can reach more than 99.5wt%. Therefore, the separation and purification process of the utility model is simple, low energy consumption, less equipment investment, no pollution, high product purity.

the annual meeting of the bio-based chemical fibers and raw materials branch of the China chemical fiber industry association was successfully held on January 23. the annual meeting of the bio-based chemical fibers and raw materials branch of the China chemical fiber industry association was successfully held in Hangzhou, Zhejiang province. Leaders from industry associations, experts and professors from colleges and universities, and representatives of leading enterprises in the upper and lower reaches of the industrial chain gathered together to exchange views on the development status, research and development innovation, application fields, social values, etc. of bio-based fibers such as polylactic acid fiber, bio-based polyamide 56 fiber, cellulose fiber, protein modified cellulose fiber, seaweed fiber and other sub-categories of raw materials, and jointly explore new ways for high-quality development of future industries. At the meeting, experts said that by 2022, the total production capacity of bio-based chemical fibers will reach 812300 tons/year, with a total output of 232000 tons.

Evonik's world's first large-scale biosurfactant rhamnolipid production plant was officially put into operation. Recently, Evonik's world's first large-scale biosurfactant rhamnolipid production plant in Slovakia has been completed ahead of schedule and officially put into operation. Evonik's rhamnolipid products are of excellent quality and are produced by fermentation using patented technology, with unique advantages in the market.

wanhua chemical new method to prepare PBAT with low acid value and antibacterial properties. recently, according to the announcement of the state intellectual property office, wanhua chemical group co., ltd. applied for a project called "a polyterephthalic acid-adipic acid-butanediol copolyester and its preparation method", publication number CN117362608A, with the application date of November 2023. In view of the shortcomings in the existing technology, Wanhua Chemical provides a poly-acid-adipic acid-butyl glycol co-polyester (PBAT) and its preparation method, which can effectively reduce the occurrence of side reactions and produce PBAT with low acid value and antibacterial properties. The PBAT prepared by the invention not only has low acid value and high hue, but also has good antibacterial properties, and has great application in the field of food packaging.

LG chemical enters the plastic chemical recycling track

recently, LG chemical (Guangzhou) engineering plastics co., ltd. (hereinafter referred to as "LG chemical (Guangzhou)") announced that the company will internally recycle the waste materials in the process of producing ABS engineering plastic boxes, reuse the transportation materials, and recycle the resources through professional recycling companies. about 2900 tons of waste have been converted to 100 percent, as a result, it has obtained the highest platinum certification of UL2799 waste zero landfill, becoming the first enterprise in the engineering plastics industry in China and South Korea to obtain the certificate. Not only that, LG Chem has previously achieved 100 percent use of renewable energy and is now the only manufacturer in the world to achieve the dual goals of 100 percent use of renewable energy and zero waste to landfill.

Shell Chemical Company and Braskem Company will cooperate

recently, Braskem Company announced cooperation and Shell Chemical Company, in the Braskem production of polypropylene using more recycled components, the production of raw materials through ISCC PLUS certification, this recycling PP will be used in packaging and automotive. Shell plans to upgrade and process pyrolysis oil from plastic waste at its newly upgraded plant at Shell Chemical Park in Modijk, the Netherlands, before sending it to Braskem polypropylene plant in Veselin, Germany, for further conversion. The upgrade unit being built can process up to 50000 tons of pyrolysis oil per year and will eliminate many impurities in the pyrolysis oil, producing higher-quality feedstocks for chemicals. This upgraded raw material can replace the traditional original fossil raw materials in the chemical industry.

FDA announced the addition of 6 CAR-T cell therapy black box warning

January 22, the FDA released the latest news that 6 cell therapy will be added on the risk of T cell malignancy black box warning. An investigation into this action will begin as early as the end of 2023. The FDA said that since the approval of each CAR-T product, its post-marketing and clinical trial data have found reports of mature T-cell cancers (including CAR-positive tumors) after using CAR-T therapies targeting BCMA and CD19, and even death in severe cases. Referring to JAK inhibitors, after the first generation of JAK inhibitors were given FDA black box warning, it was not until the emergence of highly selective TYK2 allosteric inhibitors that the shackles of the safety of JAK inhibitors in the past could be bypassed from the mechanism, thus lifting the black box warning and greatly reducing the obstacles to commercialization.

Chongqing huafeng: at present, the only independent production base of adipic acid-nylon 66 whole industry chain in China. on January 18, Chongqing science and technology development strategy research institute released the top ten scientific and technological progress of Chongqing in 2023. Chongqing huafeng "nylon 66 whole industry chain green and low carbon complete set of technology" emerged from many participating projects and was successfully selected. Chongqing Huafeng "nylon 66 whole industry chain green low-carbon complete set of technology" by Chongqing Huafeng Chemical joint Chongqing Huafeng polyamide, Chongqing Huafeng nylon fiber development, the technology has established a completely independent intellectual property rights of nylon 66 whole industry chain, completely get rid of the long-term control of foreign passive situation. Among them, Chongqing Huafeng Chemical has developed five core technologies, including 120000 tons of cyclohexane bionic oxidation process and nitrous oxide low-temperature catalytic decomposition and elimination, and built the world's largest 480000 tons/year cyclohexanol plant and 500000 tons/year adipic acid plant in June 2023. Chongqing Huafeng nylon fiber has developed the continuous polymerization technology of nylon 66 industrial yarn and built the first set of 50000 tons/year industrial plant in China.

The success of the set of technology through, let Chongqing Huafeng become the only adipic acid-nylon 66 whole industry chain independent production base.

Risk Warning

Policy Disturbance; Technology Diffusion; New Technology Breakthrough; Global Intellectual Property Dispute; Global Trade Dispute; Risk of Capacity Rush due to Tighter Carbon Emissions; Risk of Oil Price Drop; Risk of Economic Downturn.